| Congress can deliver a pain-free health care plan - | | | | incidence of less than 1/2500 should be detected |
| and the solution is right in its own back yard. In | | | | during premarket clinical studies - no exception. |
| Rockville, Maryland, actually, at the Center for | | | | But unfortunately, the general public has become |
| Drug Evaluation and Research (CDER) of the | | | | the unwitting guinea pig for the testing of new |
| Federal Food and Drug Administration (FDA), the | | | | drugs. |
| division responsible for the approval and | | | | Allowing the fox to guard the henhouse has been |
| monitoring of prescription and nonprescription | | | | a major problem for decades. Currently, drug |
| drugs. And it won't require raising taxes on the | | | | companies design, supervise and conduct all of |
| wealthy, penalizing individuals and employers who | | | | their own premarket studies, then compile the |
| don't purchase health insurance or reducing | | | | statistics, summarize them and ultimately |
| Medicare payments to medical providers. It will | | | | spoon-feed the FDA with its own spin on the |
| only require fixing the archaic and inefficient | | | | data. And the documented abuses over the years |
| methods and practices of the CDER branch of | | | | are legion. With tens of millions of dollars invested |
| the FDA. | | | | in premarket research and FDA approval the only |
| Consider these statistics... | | | | means to recoup the investment, drug companies |
| - More than 50% of all serious adverse reactions | | | | are highly biased and motivated to pursue any |
| to drugs are discovered after the drugs are | | | | and all action necessary to obtain that approval. |
| initially marketed (e.g., they are not detected | | | | POSTMARKET FDA ACTION |
| during premarket testing). | | | | When the Food and Drug Amendments Act of |
| - About 2,270,000 patients per year incur hospital | | | | 2007 was passed in September 2007, it was |
| costs as a result of adverse drug reactions. | | | | intended to extend postmarket power to CDER, |
| - Another 4,300,000 visit other health care | | | | which was to some extent lacking prior to its |
| providers (physicians, hospital outpatient | | | | passage. Yet over the past 22 months, it has |
| departments and emergency rooms) as a result | | | | shown little inclination to abandon its established |
| of adverse drug reactions. | | | | pattern of procrastination and apparent |
| - Approximately 230,000 die each year as a result | | | | indifference to the urgency of addressing a |
| of an adverse drug reaction (105,000 using drugs | | | | serious drug risk that is impacting a large segment |
| as directed and 125,000 from not following | | | | of the population. |
| directions) - the fourth leading cause of death in | | | | Within ten months after Vioxx was first |
| the United States. | | | | marketed, a study was released reporting that |
| - The total annual health care cost as a | | | | users were 3 times more likely to have a heart |
| consequence of adverse drug reactions exceeds | | | | attack than users of a competing pain reliever. |
| a staggering $200 billion - an amount equal to | | | | Yet only after 5 more incriminating studies and |
| what is spent on Medicaid every year and almost | | | | 3½ years had passed was the drug |
| half of what is spent on Medicare. | | | | removed from the market (October 2004), and |
| This cost can be cut in half - easily - by fixing | | | | then only because of the voluntary decision by |
| everything that is wrong with the FDA and the | | | | the drug's manufacturer, Merck & Co. It has |
| system of testing drugs. This would amount to | | | | been estimated that as many as 88,000 to |
| health care savings of at least $100 billion per | | | | 139,000 users of Vioxx suffered heart attacks - |
| year - one trillion dollars over ten years. | | | | 30 to 40% of them fatal - prior to its removal. |
| In general terms, this can be accomplished by | | | | This unfortunate pattern continues to this day. |
| two major changes: (1) Taking away the | | | | A CLOSER LOOK |
| premarket/pre-approval testing of drugs from the | | | | For a behind-the-scenes look at what goes on in |
| pharmaceutical companies and placing it with an | | | | the drug industry and how pharmaceutical |
| impartial and unbiased third party, such as the | | | | companies manipulate and deceive the FDA, my |
| National Institutes of Health; and (2) streamlining | | | | nonfiction book, THE PRICE OF OVULATION: the |
| CDER, such that decisions about warnings, needed | | | | Truth about Fertility Drugs and Birth Defects - |
| studies and removal of drugs from the market | | | | and a Solution to the Problem, explores in depth all |
| are promptly and efficiently made within 60 days, | | | | of the problems associated with the current |
| rather than several months, years and - in some | | | | system of testing and monitoring drugs. The book |
| instances - decades, while tens of thousands of | | | | follows the 45-plus-year history of the fertility |
| victims suffer devastating and often fatal adverse | | | | drug, Clomid, while detailing and documenting how |
| reactions to drugs. | | | | its manufacturer concealed reports of birth |
| PREMARKET STUDIES | | | | defects, disregarded requests for warnings and |
| If an adverse reaction occurs only once in | | | | further studies, and employed deceptive language |
| 100,000 users - or even once in every 10,000 - | | | | in its product labeling - all facilitated by an |
| then missing a serious side effect from a drug | | | | indifferent FDA that is more concerned about |
| might be understandable. But when the incidence | | | | rushing drugs to market than the safety of the |
| is less than 1/1000, this is not only unacceptable, it | | | | consuming public it is obligated to protect. |
| is inexcusable. When evidence of a serious and | | | | With these advocated changes, not only would |
| fatal drug reaction surfaces only three months | | | | we facilitate a plan that could pay for universal |
| after the drug was introduced on the market - as | | | | health insurance all by itself, but also save 100,000 |
| it did with Baycol (cerivastatin) - something is | | | | lives annually and immeasurable suffering in the |
| horribly wrong with our premarket testing | | | | process. |
| system. An adverse reaction that occurs at an | | | | |